The Origin of Malignant Malaria

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Malaria counts among the worst scourges of humankind, accounting for some 500 million clinical cases per year and more than one million deaths, mostly children (1). It amounts to an immeasurable health burden and inhibits economic prosperity in numerous tropical countries, most extensively in Africa. Plasmodium falciparum is the most virulent among the four Plasmodium species parasitic to humans, accounting for ≈85% of all malaria cases, and nearly all of the mortality.Downloaded from